Pesquisa Científica

A Rede LFDA trabalha na pesquisa e desenvolvimento de metodologias que sirvam à Defesa Agropecuária brasileira.

Como resultado, vários métodos desenvolvidos pelo corpo técnico da Rede LFDA alcançam publicações científicas, demonstrando a relevância das ações executadas pela Rede.

Abaixo, um compilado de artigos científicos desenvolvidos pela Rede LFDA, organizado por área de conhecimento.

Resíduos e Contaminantes em Alimentos:

2018

Jank, L., Martins, M. T., Arsand, J. B., Ferrão, M. F., Hoff, R. B., Barreto, F., & Pizzolato, T. M. (2018). An LC-ESI-MS/MS method for residues of fluoroquinolones, sulfonamides, tetracyclines and trimethoprim in feedingstuffs: validation and surveillance. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 35(10), 1975–1989. https://doi.org/10.1080/19440049.2018.1508895

Nunes, C.M., Pissinatti, R., dos Santos, E.V. (2018). Reference Material for the Determination of Polychlorodibenzo-p-dioxins, Polychlorodibenzo-furans, and Polychlorinated Biphenyls in Fish: Production Process, Homogeneity, and Stability. Food Anal. Methods: 11, 808–823. https://doi.org/10.1007/s12161-017-1062-4

Ribeiro, C. B., Martins, M. T., Jank, L., Arsand, J.B., Hoff, R. B., & Barreto, F. (2018). Development and validation of a simple and fast method for sulfonamides, tetracyclines and macrolides in honey using LC-MS/MS. Drug Analytical Research. 2: 21-28. https://doi.org/10.22456/2527-2616.84248

 2017

Lima, A. L., Barreto, F., Rau, R. B., Silva, G., Lara, L., Figueiredo, T. C., Assis, D., & Cançado, S. V. (2017). Determination of the residue levels of nicarbazin and combination nicarbazin-narasin in broiler chickens after oral administration. PloS one, 12(7), e0181755. https://doi.org/10.1371/journal.pone.0181755

de Oliveira, L. G., Barreto, F., Hoff, R., Rübensam, G., Scherer Kurz, M. H., Galle, G., & Gonçalves, F. F. (2017). Validation of a method for sedatives and β-blockers determination in swine, bovine and equine kidney using liquid chromatography coupled with tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(1), 32–39. https://doi.org/10.1080/19440049.2016.1252468

 2016

Arsand, J. B., Jank, L., Martins, M. T., Hoff, R. B., Barreto, F., Pizzolato, T. M., & Sirtori, C. (2016). Determination of aminoglycoside residues in milk and muscle based on a simple and fast extraction procedure followed by liquid chromatography coupled to tandem mass spectrometry and time of flight mass spectrometry. Talanta, 154, 38–45. https://doi.org/10.1016/j.talanta.2016.03.045

Castilhos, T. S., Barreto, F., Meneghini, L., & Bergold, A. M. (2016). Development of high-throughput multi-residue method for non-steroidal anti-inflammatory drugs monitoring in swine muscle by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(7), 1166–1174. https://doi.org/10.1080/19440049.2016.1198497

Martins, M. T., Barreto, F., HOFF, R. B., Jank, L., Arsand, J. B., Motta, T. M. C., & Schapoval, E. E. S. (2016). Multiclass and multi-residue determination of antibiotics in bovine milk by liquid chromatography-tandem mass spectrometry: combining efficiency of milk control and simplicity of routine analysis. International Dairy Journal. 59: 44-51. https://doi.org/10.1016/j.idairyj.2016.02.048

Panzenhagen, P. H., Aguiar, W. S., Gouvêa, R., de Oliveira, A. M., Barreto, F., Pereira, V. L., & Aquino, M. H. (2016). Investigation of enrofloxacin residues in broiler tissues using ELISA and LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(4), 639–643. https://doi.org/10.1080/19440049.2016.1143566

Valese, A. C., Molognoni, L., Ploêncio, L. A. S., De Lima, F. G., Gonzaga, L. V., Górniak, S. L., Daguer, H., Barreto, F., & Costa, A. C. O. (2016). A fast and simple LC-ESI-MS/MS method for detecting pyrrolizidine alkaloids in honey with full validation and measurement uncertainty. Food Control. 67: 183-191. https://doi.org/10.1016/j.foodcont.2016.02.050

Schröder, C., Pinhel, M., & Mendonça, A. O. (2016). The Brazilian strategy for monitoring persistent organic pollutants in food obtained from animals. The Science of the total environment, 573, 1370–1379. https://doi.org/10.1016/j.scitotenv.2016.07.076

 2015

Hoff, R. B., Rübensam, G., Jank, L., Barreto, F., Peralba, M., Pizzolato, T. M., Silvia Díaz-Cruz, M., & Barceló, D. (2015). Analytical quality assurance in veterinary drug residue analysis methods: matrix effects determination and monitoring for sulfonamides analysis. Talanta, 132, 443–450. https://doi.org/10.1016/j.talanta.2014.08.046

Jank, L., Martins, M. T., Arsand, J. B., Hoff, R. B., Barreto, F., & Pizzolato, T. M. (2015). High-throughput method for the determination of residues of β-lactam antibiotics in bovine milk by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(12), 1992–2001. https://doi.org/10.1080/19440049.2015.1099745

Jank, L., Martins, M. T., Arsand, J. B., Campos Motta, T. M., Hoff, R. B., Barreto, F., & Pizzolato, T. M. (2015). High-throughput method for macrolides and lincosamides antibiotics residues analysis in milk and muscle using a simple liquid-liquid extraction technique and liquid chromatography-electrospray-tandem mass spectrometry analysis (LC-MS/MS). Talanta, 144, 686–695. https://doi.org/10.1016/j.talanta.2015.06.078

Martins, M. T., Barreto, F., Hoff, R. B., Jank, L., Arsand, J. B., Feijó, T. C., & Schapoval, E. E. (2015). Determination of quinolones and fluoroquinolones, tetracyclines and sulfonamides in bovine, swine and poultry liver using LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(3), 333–341. https://doi.org/10.1080/19440049.2015.1007091

Moreira, R. P. L., Oliveira, F. A. S., Madureira, F. D., Gonçalves, M. L., & Silva, G. (2015). Multiresidue analysis of pesticide in peanuts using modified QuEChERS sample preparation and Liquid Chromatography-Mass Spectrometry detection. Analytical Methods. 7: 4734-4739. https://doi.org/10.1039/C5AY00331H

Ribeiro, R. F. L., Germano, A. (2015). Development and validation of a method for the determination of Hg in animal tissues (equine muscle, bovine kidney and swine kidney, and poultry muscle) by direct mercury analysis (DMA). Microchemical Journal. 121:237-243. https://doi.org/10.1016/j.microc.2015.03.005

2014

Alkmim Filho, J. F., Germano, A., Dibai, W. L. S., Vargas, E. A., & Melo, M. M. (2014). Assessment of heavy metal residues in Brazilian poultry and swine tissue. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 66(2), 471–480. https://doi.org/10.1590/1678-41626990

Hoff, R. B., Barreto, F., Melo, J., Martins, M. T., Pizzolato, T. M., & Peralba, M. (2014). Scope extension validation protocol: inclusion of analytes and matrices in an LC-MS/MS sulfonamide residues method. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 31(1), 39–47. https://doi.org/10.1080/19440049.2013.861082

Martins, M. T., Melo, J., Barreto, F., Hoff, R. B., Jank, L., Bittencourt, M. S., Arsand, J. B., & Schapoval, E. E. (2014). A simple, fast and cheap non-SPE screening method for antibacterial residue analysis in milk and liver using liquid chromatography-tandem mass spectrometry. Talanta, 129, 374–383. https://doi.org/10.1016/j.talanta.2014.04.049

Meneghini, L. Z., Rübensam, G., Bica, V. C., Ceccon, A., Barreto, F., Ferrão, M. F., & Bergold, A. M. (2014). Multivariate optimization for extraction of pyrethroids in milk and validation for GC-ECD and CG-MS/MS analysis. International journal of environmental research and public health, 11(11), 11421–11437. https://doi.org/10.3390/ijerph111111421

Campos Motta, T. M., Hoff, R. B., Barreto, F., Andrade, R. B., Lorenzini, D. M., Meneghini, L. Z., & Pizzolato, T. M. (2014). Detection and confirmation of milk adulteration with cheese whey using proteomic-like sample preparation and liquid chromatography-electrospray-tandem mass spectrometry analysis. Talanta, 120, 498–505. https://doi.org/10.1016/j.talanta.2013.11.093

 2013

Carneiro, R. P., Oliveira, F. A. S., Madureira, F. D., Silva, G., De Souza, W. R., & Lopes, R. P. (2013). Development and method validation for determination of 128 pesticides in bananas by modified QuEChERS and UHPLC-MS/MS analysis. Food Control. 33: 413-423. https://doi.org/10.1016/j.foodcont.2013.02.027

Damin, I. C., Santo, M. A., Hennigen, R., & Vargas, D. M. (2013). Validation of a hydride generation atomic absorption spectrometry methodology for determination of mercury in fish designed for application in the Brazilian national residue control plan. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 48(12), 1103–1111. https://doi.org/10.1080/03601234.2013.824303

Dias, C. M., Oliveira, F. A., Madureira, F. D., Silva, G., Souza, W. R., & Cardeal, Z. L. (2013). Multi-residue method for the analysis of pesticides in Arabica coffee using liquid chromatography/tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 30(7), 1308–1315. https://doi.org/10.1080/19440049.2013.801088

Filho, J. F. A., Germano, A., Dibai, W. L. S., Vargas, E. A., Melo, M. M., Zmozinski, A. V., Passos, L. D., Damin, I. C. F., Espírito Santo, M.A.B., Vale, M. G. R., & Silva, M. M. (2013). Determination of cadmium and lead in fresh fish samples by direct sampling electrothermal atomic absorption spectrometry. Analytical Methods. 5: 6416-6424.

Rübensam, G., Barreto, F., Hoff, R. B., & Pizzolato, T. M. (2013). Determination of avermectin and milbemycin residues in bovine muscle by liquid chromatography-tandem mass spectrometry and fluorescence detection using solvent extraction and low temperature cleanup. Food Control. 29: 55-60. https://doi.org/10.1016/j.foodcont.2012.05.075

2012

Almeida, M. I., Almeida, N.G., Carvalho, K.L., Gonçalves, G.A.A., Silva, C.N., Santos, E.A., Garcia, J. C., & Vargas, E. A. (2012). Co-occurrence of aflatoxins B 1 , B 2 , G 1 and G 2 , ochratoxin A , zearalenone , deoxynivalenol , and citreoviridin in rice in Brazil. Food Additives & Contaminants : Part A : Chemistry , Analysis , Control , Exposure & Risk Assessment, 29(4), 694-703.
https://doi.org/10.1080/19440049.2011.651750

Almeida, M. P., Rezende, C. P., Souza, L. F., & Brito, R. B. (2012). Validation of a quantitative and confirmatory method for residue analysis of aminoglycoside antibiotics in poultry, bovine, equine and swine kidney through liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 517–525. https://doi.org/10.1080/19440049.2011.623681

Ascari, J., Dracz, S., Santos, F. A., Lima, J. A., Diniz, M. H., & Vargas, E. A. (2012). Validation of an LC-MS/MS method for malachite green (MG), leucomalachite green (LMG), crystal violet (CV) and leucocrystal violet (LCV) residues in fish and shrimp. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 602–608. https://doi.org/10.1080/19440049.2011.653695

Barreto, F., Ribeiro, C., Hoff, R. B., & Costa, T. D. (2012). Determination and confirmation of chloramphenicol in honey, fish and prawns by liquid chromatography-tandem mass spectrometry with minimum sample preparation: validation according to 2002/657/EC Directive. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 550–558. https://doi.org/10.1080/19440049.2011.641160

Bittencourt, M. S., Martins, M. T., de Albuquerque, F. G., Barreto, F., & Hoff, R. (2012). High-throughput multiclass screening method for antibiotic residue analysis in meat using liquid chromatography-tandem mass spectrometry: a novel minimum sample preparation procedure. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 508–516. https://doi.org/10.1080/19440049.2011.606228

Carvalho, K. L., Gonçalves, G. A., Lopes, A. L., Santos, E. A., Vargas, E. A., & Magalhães, W. F. (2012). Modelling uncertainty estimation for the determination of aflatoxin M(1) in milk by visual and densitometric thin-layer chromatography with immunoaffinity column clean-up. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 679–693. https://doi.org/10.1080/19440049.2011.648959

Cunha, A. L., Silva, P. F., Souza, E. A., Júnior, J. R., Santos, F. A., & Vargas, E. A. (2012). Producing a sulfamethazine quality control material under the framework of ISO/CD Guide 80. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 571–576. https://doi.org/10.1080/19440049.2011.641162

Fleury Filho, N., Nascimento, C. A., Faria, E. O., Cruvinel, A. R., & Oliveira, J. M. (2012). Within-laboratory validation of a multiresidue method for the analysis of 98 pesticides in mango by liquid chromatography-tandem mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 641–656. https://doi.org/10.1080/19440049.2011.606230

Hoff, R., Ribarcki, F., Zancanaro, I., Castellano, L., Spier, C., Barreto, F., & Fonseca, S. H. (2012). Bioactivity-based screening methods for antibiotics residues: a comparative study of commercial and in-house developed kits. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 577–586. https://doi.org/10.1080/19440049.2011.641508

Hoff, R. B., Barreto, F., Melo, J., Jank, L., Peralba, M. C. R., & Pizzolato, T. M. (2012). Characterization and estimation of sulfaquinoxaline metabolites in animal tissues using liquid chromatography coupled to tandem mass spectrometry. Analytical Methods, 4: 2822-2830.

Jank, L., Hoff, R. B., Tarouco, P. C., Barreto, F., & Pizzolato, T. M. (2012). β-lactam antibiotics residues analysis in bovine milk by LC-ESI-MS/MS: a simple and fast liquid-liquid extraction method. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 497–507. https://doi.org/10.1080/19440049.2011.604044

Lara, P. C., Fabrino, H. J., Germano, A., & Silva, J. B. (2012). Development and validation of a method for Cd, Pb and As analysis in bovine, equine and poultry liver by inductively coupled plasma mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 609–616. https://doi.org/10.1080/19440049.2011.608381

Lins, E. S., Conceição, E. S., & Mauricio, A. (2012). Evolution of a residue laboratory network and the management tools for monitoring its performance. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 490–496. https://doi.org/10.1080/19440049.2011.653988

Madureira, F. D., da Silva Oliveira, F. A., de Souza, W. R., Pontelo, A. P., de Oliveira, M. L., & Silva, G. (2012). A multi-residue method for the determination of 90 pesticides in matrices with a high water content by LC-MS/MS without clean-up. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 665–678. https://doi.org/10.1080/19440049.2011.623837

Magalhães, C. G., De Paiva, C. R., Botelho, B. G., De Oliveira, A. M., De Souza, L. F., Nonaka, C. V., Santos, K. V., Farias, L. M., & Carvalho, M. A. (2012). In-house validation of PremiTest, a microbiological screening test with solvent extraction, for the detection of antimicrobial residues in poultry muscles. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 535–540. https://doi.org/10.1080/19440049.2011.627571

de Queiroz Mauricio, A., & Lins, E. S. (2012). The National Agricultural Laboratories of Brazil and the control of residues and contaminants in food. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 482–489. https://doi.org/10.1080/19440049.2011.620987

Nonaka, C. K., Oliveira, A. M., Paiva, C. R., Almeida, M. P., Rezende, C. P., Moraes, C. G., Botelho, B. G., Souza, L. F., & Dias, P. G. (2012). Occurrence of antimicrobial residues in Brazilian food animals in 2008 and 2009. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 526–534. https://doi.org/10.1080/19440049.2011.625649

de Oliveira, M. L., Madureira, F. D., Aurélio, F., Pontelo, A. P., Silva, G., Oliveira, R., & Paes, C. (2012). A multi-residue method for the determination of pesticides in high water content matrices by gas chromatography-single quadrupole mass spectrometry with electron ionisation (EI-GC/MS). Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 657–664. https://doi.org/10.1080/19440049.2011.642102

Olivares, I. R. B., Lopes, F. A., Queiroz, H. M., Saglioni, E. M. C., Kowalsky, C. H., Modro, A. L. (2012). Fit for purpose validation: understanding different protocols of the European Community to analyse residues and contaminants in Brazilian food. Food Additives & Contaminants 29:04

Olivares, I. R. B., Lopes, F. A. (2012). Analytical Quality Assurance Cycle: Trends and Essential Steps to Provide Reliable Results. (TrAC) Trends in Analytical Chemistry (Regular ed.)

Picinin, L. C. A., Cerqueira, M. M. O. P., Vargas, E. A., Lana, Â. M. Q., Toaldo, I. M., & Bordignon-Luiz, M. T. (2012). Influence of climate conditions on Aflatoxin M1 contamination in raw milk from Minas Gerais State, Brazil. Food Control. 31:419: 424. https://doi.org/10.1016/j.foodcont.2012.10.024

Rezende, C. P., Almeida, M. P., Brito, R. B., Nonaka, C. K., & Leite, M. O. (2012). Optimisation and validation of a quantitative and confirmatory LC-MS method for multi-residue analyses of β-lactam and tetracycline antibiotics in bovine muscle. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 541–549. https://doi.org/10.1080/19440049.2011.627883

Rezende, C. P., Souza, L. F., Almeida, M. P., Dias, P. G., Diniz, M. H., & Garcia, J. C. (2012). Optimisation and validation of a quantitative and confirmatory method for residues of macrolide antibiotics and lincomycin in kidney by liquid chromatography coupled to mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 587–595. https://doi.org/10.1080/19440049.2011.652196

Rezende, D. R., Filho, N. F., & Rocha, G. L. (2012). Simultaneous determination of chloramphenicol and florfenicol in liquid milk, milk powder and bovine muscle by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 559–570. https://doi.org/10.1080/19440049.2011.641161

Torres, D. P., Martins-Teixeira, M. B., Silva, E. F., & Queiroz, H. M. (2012). Method development for the control determination of mercury in seafood by solid-sampling thermal decomposition amalgamation atomic absorption spectrometry (TDA AAS). Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(4), 625–632. https://doi.org/10.1080/19440049.2011.642310

 2011

Lopes, R. P., Augusti, D. V., Souza, L. F., Santos, F. A., Lima, J. A., Vargas, E. A., & Augusti, R. (2011). Development and validation (according to the 2002/657/EC regulation) of a method to quantify sulfonamides in porcine liver by fast partition at very low temperature and LC-MS/MS. Analytical Methods. 3: 606-613. https://doi.org/10.1039/C0AY00587H

Lopes, R. P., Augusti, D. V., Oliveira, A. G., Oliveira, F. A., Vargas, E. A., & Augusti, R. (2011). Development and validation of a methodology to qualitatively screening veterinary drugs in porcine muscle via an innovative extraction/clean-up procedure and LC-MS/MS analysis. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(12), 1667–1676. https://doi.org/10.1080/19440049.2011.609136

Rübensam, G., Barreto, F., Hoff, R. B., Kist, T. L., & Pizzolato, T. M. (2011). A liquid-liquid extraction procedure followed by a low temperature purification step for the analysis of macrocyclic lactones in milk by liquid chromatography-tandem mass spectrometry and fluorescence detection. Analytica chimica acta, 705(1-2), 24–29. https://doi.org/10.1016/j.aca.2011.02.041

Vargas, E. A., dos Santos, E. A., Whitaker, T. B., & Slate, A. B. (2011). Determination of aflatoxin risk components for in-shell Brazil nuts. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(9), 1242–1260. https://doi.org/10.1080/19440049.2011.596488

2009

Mauricio, A., Lins, E. S., & Alvarenga, M. B. (2009). A National Residue Control Plan from the analytical perspective--the Brazilian case. Analytica chimica acta, 637(1-2), 333–336. https://doi.org/10.1016/j.aca.2008.09.061

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