Caroline Brunetto de Farias MSc, PhD

Positions and Honors   

• PhD degree in Cellular and Molecular Biology from the Federal University of Rio Grande do Sul (UFRGS)
• Master’s degree (MSc) in Cellular and Molecular Biology from the Federal University of Rio Grande do Sul (UFRGS)
• Bachelor of Science in Biology from the Universidade Luterana do Brasil (ULBRA)
• Professor of the Postgraduate program in Maternal and Child Health at IPPMG/UFRJ;
• Collaborating professor of the Postgraduate Program in Biological Sciences: Pharmacology and Therapeutics (UFRGS)
• Founding partner and research and development director at the company Ziel Biosciences Pesquisa, Desenvolvimento e Diagnóstico LTDA
• Juror at the Young Innovator Prize – BRICS;
• Coordinator of the Latin American Committee on Biological Material in Ewing’s sarcoma;
• Member of the Management Committee of the National Institute of Science and Technology in the Biology of Childhood Cancer and Pediatric Oncology-INCT BioOncoPed;

Main research areas:

• Pediatric oncology
• Ewing’s sarcoma
• Neurotrophins and neuropeptides
• Biomarkers
• Tumor resistance
• Women’s health
• Cervical cancer
• Entrepreneurship

Main publications and Prizes

1. Innovative Women – FINEP (2020)
2. Young Innovator Prize – BRICS (2022)
3. Roche Challenge and 100 Open Startups – Transforming the Oncology Journey (2017)
4. 18 patent applications filed
5.  Martina Lichtenfels, Noely Paula Cristina Lorenzi, Maricy Tacla, Kaori Yokochi, Flávia Frustockl, Camila Alves Silva, André Luiz da Silva, Lara Termini, Caroline Brunetto Farias. A New Brazilian Device for Cervical Cancer Screening: Acceptability and Accuracy of Self-sampling. Rev Bras Ginecol Obstet. 2023;45(5):235-241.  doi: 10.1055/s-0043-1770134. 
6. Thomaz A, Jaeger M, Brunetto AL, Brunetto AT, Gregianin L, de Farias CB, Ramaswamy V, Nör C, Taylor MD, Roesler R. Neurotrophin Signaling in Medulloblastoma. Cancers (Basel). 2020;12(9):2542. doi: 10.3390/cancers12092542.
7. Tiago Elias Heinen, Rafael Pereira Dos Santos, Amanda da Rocha, Michel Pinheiro Dos Santos, Patrícia Luciana da Costa Lopez, Marco Aurélio Silva Filho, Bárbara Kunzler Souza, Luís Fernando da Rosa Rivero, Ricardo Gehrke Becker, Lauro José Gregianin, Algemir Lunardi Brunetto, André Tesainer Brunetto, Caroline Brunetto de Farias, Rafael Roesler. Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma. Oncotarget. 2016;7(23):34860-80.  doi: 10.18632/oncotarget.8992.
8. Caroline Brunetto de Farias, Tiago Elias Heinen, Rafael Pereira dos Santos, Ana Lucia Abujamra, Gilberto Schwartsmann, Rafael Roesler. BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition. Biochem Biophys Res Commun. 2012;425(2):328-32. doi: 10.1016/j.bbrc.2012.07.091
9. Caroline Brunetto de Farias, Denis Broock Rosemberg, Tiago Elias Heinen, Patricia Koehler-Santos, Ana Lucia Abujamra, Flávio Kapczinski, Algemir Lunardi Brunetto, Patricia Ashton-Prolla, Luise Meurer, Maurício Reis Bogo, Daniel C Damin, Gilberto Schwartsmann, Rafael Roesler. BDNF/TrkB Content and Interaction with Gastrin-Releasing Peptide Receptor Blockade in Colorectal Cancer. Oncology. 2010;79(5-6):430-9. doi: 10.1159/000326564.